GLB1 antibody

Catalog No. ABIN2855812

Product Details anti-GLB1 Antibody

Target: GLB1 (Galactosidase, beta 1 (GLB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Rat

Characteristics: Rabbit polyclonal antibody to beta-Gal (galactosidase, beta 1)
beta-Gal antibody [N2C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human beta-Gal. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.35 mg/mL

Buffer: 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-GLB1 antibody (ABIN2855812)

Chang, Su, Chen, Chen, Chen, Hsiao: "Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis." in: Molecular cancer, Vol. 16, Issue 1, pp. 135, (2018) (PubMed).

Target Details for GLB1

Target: GLB1 (Galactosidase, beta 1 (GLB1))

Alternative Name: galactosidase beta 1 (GLB1 Products)

Synonyms: EBP antibody, ELNR1 antibody, MPS4B antibody, DER antibody, XR antibody, 0610038K04Rik antibody, 1810027P18Rik antibody, glb antibody, CG9092 antibody, Dmel\\CG9092 antibody, beta-GAL antibody, beta-Gal-1 antibody, beta-gal antibody, gal antibody, lacZ-1 antibody, AW125515 antibody, Bge antibody, Bgl antibody, Bgl-e antibody, Bgl-s antibody, Bgl-t antibody, Bgs antibody, Bgt antibody, C130097A14Rik antibody, BGAL antibody, zgc:110823 antibody, ECK0341 antibody, JW0335 antibody, GLB antibody, galactosidase beta 1 antibody, dicarbonyl and L-xylulose reductase antibody, dicarbonyl L-xylulose reductase antibody, beta-D-galactosidase antibody, beta-galactosidase antibody, beta galactosidase antibody, galactosidase, beta 1 antibody, beta-galactosidase-like antibody, GLB1 antibody, DCXR antibody, Dcxr antibody, lacZ antibody, SSP_RS00525 antibody, lacH antibody, ECL_03691 antibody, Gal antibody, Glb1 antibody, glb1 antibody, VV2_1327 antibody, LOC100056371 antibody

Background: This gene encodes beta-galactosidase-1, a lysosomal enzyme that hydrolyzes the terminal beta-galactose from ganglioside substrates and other glycoconjugates. Defects in this gene are the cause of GM1-gangliosidosis and Morquio B syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.

Cellular Localization: Isoform 1: Lysosome , Isoform 2: Cytoplasm , perinuclear region

Molecular Weight: 76 kDa

Gene ID: 2720

UniProt: P16278

Pathways: Glycosaminoglycan Metabolic Process