PSMC6 antibody

Catalog No. ABIN2855808

Product Details anti-PSMC6 Antibody

Target: PSMC6 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 (PSMC6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMC6 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit Polyclonal antibody to PSMC6 (proteasome (prosome, macropain) 26S subunit, ATPase, 6)
PSMC6 antibody

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human PSMC6. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Mouse brain , 293T

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for PSMC6

Target: PSMC6 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 6 (PSMC6))

Alternative Name: proteasome 26S subunit, ATPase 6 (PSMC6 Products)

Synonyms: DDBDRAFT_0186051 antibody, DDBDRAFT_0232968 antibody, DDB_0186051 antibody, DDB_0232968 antibody, fb20g04 antibody, wu:fb20g04 antibody, wu:fc85c10 antibody, cadp44 antibody, sug2 antibody, PSMC6 antibody, psmc6-a antibody, NV13405 antibody, CADP44 antibody, P44 antibody, SUG2 antibody, p42 antibody, 2300001E01Rik antibody, AI451058 antibody, 26S protease regulatory subunit S10B antibody, 26S proteasome regulatory subunit 10B antibody, proteasome 26S subunit, ATPase 6 antibody, proteasome 26S subunit, ATPase 6 L homeolog antibody, 26S protease regulatory subunit 10B antibody, proteasome 26S subunit, ATPase 6 S homeolog antibody, proteasome (prosome, macropain) 26S subunit, ATPase, 6 antibody, ATEG_02903 antibody, HCAG_04181 antibody, LOC5565051 antibody, EDI_289460 antibody, CpipJ_CPIJ003334 antibody, EHI_194070 antibody, PTRG_02716 antibody, BDBG_01801 antibody, psmC6 antibody, MCYG_07206 antibody, PITG_00229 antibody, VDBG_04729 antibody, MGYG_04704 antibody, TERG_01608 antibody, DICPUDRAFT_97252 antibody, Tsp_02519 antibody, prs10 antibody, LOC100282100 antibody, Psmc6 antibody, psmc6 antibody, psmc6.L antibody, PSMC6 antibody, LOC693577 antibody, psmc6.S antibody, LOC100117671 antibody

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.

Cellular Localization: Cytoplasm (By similarity) , Nucleus

Molecular Weight: 44 kDa

Gene ID: 5706

UniProt: P62333

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway