FPGT antibody

Catalog No. ABIN2855758

Product Details anti-FPGT Antibody

Target: FPGT (Fucose-1-Phosphate Guanylyltransferase (FPGT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FPGT antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to FPGT (fucose-1-phosphate guanylyltransferase)
FPGT antibody [N2C2], Internal

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human FPGT. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: Raji

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.74 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for FPGT

Target: FPGT (Fucose-1-Phosphate Guanylyltransferase (FPGT))

Alternative Name: fucose-1-phosphate guanylyltransferase (FPGT Products)

Synonyms: DDBDRAFT_0186414 antibody, DDBDRAFT_0233144 antibody, DDB_0186414 antibody, DDB_0233144 antibody, FPGT antibody, DKFZp459M111 antibody, fpgt antibody, zgc:110694 antibody, GFPP antibody, 1700016E03Rik antibody, fucose-1-phosphate guanylyltransferase antibody, fucose-1-phosphate guanylyltransferase L homeolog antibody, fpgt antibody, FPGT antibody, fpgt.L antibody, Fpgt antibody

Background: L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose, the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose.

Cellular Localization: Cytoplasm

Molecular Weight: 67 kDa

Gene ID: 8790

UniProt: O14772