L3MBTL1 antibody (Center)

Catalog No. ABIN2855703

Product Details anti-L3MBTL1 Antibody

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Binding Specificity: Center

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L3MBTL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Cross-Reactivity: Mouse (Murine)

Cross-Reactivity (Details): mouse (88 %)

Characteristics: Rabbit polyclonal antibody to L3MBTL (l(3)mbt-like (Drosophila))
L3MBTL antibody

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human L3MBTL. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference ICC/IF 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* Western blot1:500-1:3000*

Comment:

Positive Control: HeLaS3 , human L3MBTL-transfected 293T

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-L3MBTL1 antibody (ABIN2855703)

Lu, Periz, Lu, Tang, Liu, Zhang, Shah, Thombre, Aljumaah, Li, Mojsilovic-Petrovic, Ji, Johnson, Kalb, Wang: "L3MBTL1 regulates ALS/FTD-associated proteotoxicity and quality control." in: Nature neuroscience, Vol. 22, Issue 6, pp. 875-886, (2019) (PubMed).

Target Details for L3MBTL1

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Alternative Name: L3MBTL (L3MBTL1 Products)

Synonyms: C630004G01 antibody, L3mbtl antibody, mKIAA0681 antibody, H-L(3)MBT antibody, L3MBTL antibody, ZC2HC3 antibody, dJ138B7.3 antibody, RGD1307316 antibody, l(3)mbt-like (Drosophila) antibody, L3MBTL1, histone methyl-lysine binding protein antibody, l(3)mbt-like 1 (Drosophila) antibody, L3mbtl1 antibody, L3MBTL1 antibody

Background: This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Cellular Localization: Nucleus

Molecular Weight: 84 kDa

Gene ID: 26013

Pathways: Chromatin Binding