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FGFRL1 antibody

FGFRL1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2855700
  • Target See all FGFRL1 Antibodies
    FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))
    Reactivity
    • 51
    • 13
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 52
    • 1
    • 1
    Rabbit
    Clonality
    • 52
    • 2
    Polyclonal
    Conjugate
    • 19
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FGFRL1 antibody is un-conjugated
    Application
    • 42
    • 22
    • 21
    • 13
    • 13
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human
    Characteristics
    Rabbit polyclonal antibody to FGFR-5 (fibroblast growth factor receptor-like 1)
    FGFR-5 antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human FGFR5. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product FGFRL1 Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: FGFRL1-transfected 293T , HepG2 membrane extract

    Validation: Orthogonal, Overexpression

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    2.42 mg/mL
    Buffer
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))
    Alternative Name
    fibroblast growth factor receptor like 1 (FGFRL1 Products)
    Synonyms
    fgfrl1 antibody, zgc:64084 antibody, FGFR5 antibody, FGFR5beta antibody, FGFR5gamma antibody, Fgfr5 antibody, FHFR antibody, XFGFRL1 antibody, Xndk antibody, fgfrl1-a antibody, fgfrl1-b antibody, ndk antibody, im:7154242 antibody, fibroblast growth factor receptor like 1a antibody, fibroblast growth factor receptor-like 1 antibody, fibroblast growth factor receptor like 1 antibody, fibroblast growth factor receptor like 1 L homeolog antibody, fibroblast growth factor receptor like 1b antibody, fgfrl1a antibody, Fgfrl1 antibody, FGFRL1 antibody, fgfrl1.L antibody, fgfrl1b antibody
    Background
    The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.

    Cellular Localization: Membrane, Single-pass type I membrane protein
    Molecular Weight
    55 kDa
    Gene ID
    53834
    UniProt
    Q8N441
    Pathways
    RTK Signaling
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