BACE1 antibody

Catalog No. ABIN2855695

Product Details anti-BACE1 Antibody

Target: BACE1 (Beta-secretase 1 (BACE1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BACE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Mouse, Rat

Characteristics: Rabbit Polyclonal antibody to BACE1 (beta-site APP-cleaving enzyme 1)
BACE1 antibody [N1C2]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human BACE1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.91 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for BACE1

Target: BACE1 (Beta-secretase 1 (BACE1))

Alternative Name: beta-secretase 1 (BACE1 Products)

Synonyms: ASP2 antibody, BACE antibody, HSPC104 antibody, C76936 antibody, Bace antibody, MGC145931 antibody, BACE1 antibody, zgc:77409 antibody, beta-secretase 1 antibody, beta-site APP cleaving enzyme 1 antibody, beta-site APP-cleaving enzyme 1 antibody, BACE1 antibody, Bace1 antibody, bace1 antibody

Background: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Four transcript variants encoding different isoforms have been described for this gene.

Cellular Localization: Membrane

Molecular Weight: 56 kDa

Gene ID: 23621

UniProt: P56817