Exportin 2 antibody (Center)

Catalog No. ABIN2855534

Product Details anti-Exportin 2 Antibody

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exportin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Cross-Reactivity: Pig (Porcine), Rhesus Monkey, Cow (Bovine)

Cross-Reactivity (Details): Pig (100 %), Rhesus Monkey (100 %), Bovine (100 %)

Characteristics: Rabbit Polyclonal antibody to CSE1L (CSE1 chromosome segregation 1-like (yeast))
CSE1L antibody

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human CSE1L. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Immunoprecipitation Assay-dependent dilution Western blot 1:500-1:10000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* ImmunoprecipitationAssay-dependent dilution Western blot1:500-1:10000*

Comment:

Positive Control: NIH-3T3 , JC , BCL-1 , C2C12 , 293T , A431 , HeLa , HepG2 , A375 , PC-12 , Rat2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.71 mg/mL

Buffer: 1XPBS, 20 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Alternative Name: CSE1L (CSE1L Products)

Synonyms: BcDNA:LD14270 antibody, CAS antibody, CG13281 antibody, Dcas antibody, Dmel\\CG13281 antibody, cas antibody, dcas antibody, l(2)k03902 antibody, CSE1L antibody, XPO2 antibody, Exportin-2 antibody, DKFZp459E1929 antibody, 2610100P18Rik antibody, AA407533 antibody, Capts antibody, Cas antibody, Xpo2 antibody, xpo2 antibody, CSE1 antibody, CAS/CSE1 segregation protein antibody, chromosome segregation 1 like antibody, exportin-2 antibody, chromosome segregation 1-like (S. cerevisiae) antibody, CSE1 chromosome segregation 1-like (yeast) antibody, CSE1 chromosome segregation 1-like L homeolog antibody, Cas antibody, CSE1L antibody, LOC100542094 antibody, cse1l antibody, Cse1l antibody, cse1l.L antibody

Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.

Cellular Localization: Cytoplasm , Nucleus

Molecular Weight: 110 kDa

Gene ID: 1434

Pathways: Protein targeting to Nucleus