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PTPN12 antibody (N-Term)

PTPN12 Reactivity: Human WB, IHC (p), IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2855422
  • Target See all PTPN12 Antibodies
    PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))
    Binding Specificity
    • 15
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 55
    • 11
    • 9
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    Human
    Host
    • 49
    • 6
    Rabbit
    Clonality
    • 50
    • 5
    Polyclonal
    Conjugate
    • 31
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PTPN12 antibody is un-conjugated
    Application
    • 43
    • 14
    • 13
    • 13
    • 11
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Cross-Reactivity
    Human, Rat
    Characteristics
    Rabbit Polyclonal antibody to PTPN12 (protein tyrosine phosphatase, non-receptor type 12)
    PTPN12 antibody [N1N2], N-term
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the N-terminus region of human PTPN12. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product PTPN12 Primary Antibody
  • Application Notes
    WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: HeLa

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.93 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))
    Alternative Name
    protein tyrosine phosphatase non-receptor type 12 (PTPN12 Products)
    Synonyms
    PTP-PEST antibody, PTPG1 antibody, P19-PTP antibody, PTP-P19 antibody, Ptpg1 antibody, RKPTP antibody, protein tyrosine phosphatase, non-receptor type 12 antibody, PTPN12 antibody, Ptpn12 antibody
    Background
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

    Cellular Localization: Cytoplasm
    Molecular Weight
    88 kDa
    Gene ID
    5782
    UniProt
    Q05209
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