TALDO1 antibody (N-Term)

Catalog No. ABIN2855282

Product Details anti-TALDO1 Antibody

Target: TALDO1 (Transaldolase 1 (TALDO1))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TALDO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit Polyclonal antibody to Transaldolase (transaldolase 1)
Transaldolase antibody

Purification: Affinity purified by Protein A.

Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of human Transaldolase. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: A431 , Mouse brain

Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 6.48 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-TALDO1 antibody (ABIN2855282)

Ding, Gong, Huang, Chen, Sui, Lin, Liang, Yuan, Xiang, Chen, Yin, Alexander, Wang, Song, Li, Wood, Wang: "Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers." in: Nature communications, Vol. 9, Issue 1, pp. 4274, (2018) (PubMed).

Target Details for TALDO1

Target: TALDO1 (Transaldolase 1 (TALDO1))

Alternative Name: transaldolase 1 (TALDO1 Products)

Background: Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.

Cellular Localization: Cytoplasm

Molecular Weight: 38 kDa

Gene ID: 6888

UniProt: P37837