CAD antibody (C-Term)
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- Target See all CAD Antibodies
- CAD (Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase (CAD))
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CAD antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human, Mouse
- Characteristics
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Rabbit Polyclonal antibody to CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase)
CAD antibody [C2C3], C-term - Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the C-terminus region of human CAD. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product CAD Primary Antibody
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- Application Notes
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Comment
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Positive Control: 293T , C2C12
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.41 mg/mL
- Buffer
- 1XPBS ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- CAD (Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase (CAD))
- Alternative Name
- carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD Products)
- Synonyms
- Cpad antibody, AU018859 antibody, 2410008J01Rik antibody, cb456 antibody, wu:fc30c12 antibody, wu:fc33d01 antibody, wu:fc67g02 antibody, si:dkey-221h15.3 antibody, CAD antibody, xcad antibody, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase antibody, CAD antibody, Cad antibody, cad antibody
- Background
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The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
Cellular Localization: Cytoplasm - Molecular Weight
- 243 kDa
- Gene ID
- 790
- UniProt
- P27708
- Pathways
- Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process
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