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Insulin Receptor antibody (C-Term)

Name: Insulin Receptor antibody (C-Term)
Brand: antibodies-online
SKU: ABIN2854945
Price: 637.78 USD
Availability: InStock

KO Validated INSR Reactivity: Human WB, ICC, IF, IHC (p) Host: Rabbit Polyclonal unconjugated

WB Image Insulin Receptor beta subunit antibody detects Insulin Receptor beta subunit protein by western blot analysis. (Insulin Receptor antibody (C-Term))

IHC-P Image Insulin Receptor antibody detects Insulin Receptor protein at membrane on mouse prostate by immunohistochemical analysis. (Insulin Receptor antibody (C-Term))

IHC

IHC-P Image Insulin Receptor antibody detects INSR protein at cytosol on human gastric cancer by immunohistochemical analysis. (Insulin Receptor antibody (C-Term))

IHC

WB Image Sample (30 ug of whole cell lysate) A: NIH-3T3 5% SDS PAGE antibody diluted at 1:1000 (Insulin Receptor antibody (C-Term))

4 images

Catalog No. ABIN2854945

Datasheet as PDF

Target See all Insulin Receptor (INSR) Antibodies

Insulin Receptor (INSR)
Binding Specificity
16

14

12

11

8

8

8

5

5

5

4

4

4

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
Reactivity
168

87

76

17

12

9

8

7

6

6

4

3

2

2

1

1

1

1

1

1

1

1
Human
Host
157

25

2

1
Rabbit
Compatible Secondaries
Clonality
146

39
Polyclonal
Conjugate
118

15

14

5

4

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
This Insulin Receptor antibody is un-conjugated
Application
133

77

53

32

18

14

14

14

13

13

9

5

4

4

3

2

2

2

1

1

1

1
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity

Human, Mouse, Rat, Zebrafish (Danio rerio)

Characteristics

Rabbit Polyclonal antibody to Insulin Receptor (insulin receptor)
Insulin Receptor antibody

Purification

Purified by antigen-affinity chromatography.

Grade

KO Validated

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of human Insulin Receptor. The exact sequence is proprietary.

Isotype

IgG

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INSR Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

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INSR Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

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INSR Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 27-57), (N-Term) antibody
INSR Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB1421 unconjugated

anti-Insulin Receptor (INSR) (C-Term) antibody
INSR Reactivity: Human, Mouse, Rat, Dog, Monkey, Horse, Cow, Guinea Pig, Rabbit, Pig, Chicken, Sheep, Hamster, Avian, Cat, Donkey, Goat WB Host: Goat Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 1325-1358) antibody
INSR Reactivity: Mouse WB Host: Rabbit Polyclonal RB50340 unconjugated

anti-Insulin Receptor (INSR) (AA 1023-1298) antibody
INSR Reactivity: Human IHC, ELISA, IF Host: Rabbit Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 51-150) antibody
INSR Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

anti-Insulin Receptor (INSR) (AA 28-57), (N-Term) antibody
INSR Reactivity: Mouse WB, IHC (p) Host: Rabbit Polyclonal RB01419 unconjugated

Application Notes

WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment

Positive Control: NIH-3T3 , PC-12 , rat liver
Validation: KO/KD

Restrictions

For Research Use only
Format

Liquid

Concentration

1.31 mg/mL

Buffer

1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

Preservative

ProClin

Precaution of Use

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C,-20 °C

Storage Comment

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Target

Insulin Receptor (INSR)

Alternative Name

insulin receptor (INSR Products)

Background

After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.

Cellular Localization: Membrane, Single-pass type I membrane protein

Molecular Weight

156 kDa

Gene ID

3643

UniProt

P06213

Pathways

NF-kappaB Signaling, RTK Signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity