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ube3a antibody

ube3a Reactivity: Human IF, IHC (p), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2854930
  • Target See all ube3a Antibodies
    ube3a (Ubiquitin Protein Ligase E3A (ube3a))
    Reactivity
    • 51
    • 11
    • 8
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 47
    • 4
    Rabbit
    Clonality
    • 46
    • 5
    Polyclonal
    Conjugate
    • 28
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ube3a antibody is un-conjugated
    Application
    • 28
    • 17
    • 16
    • 13
    • 13
    • 8
    • 8
    • 8
    • 4
    • 3
    • 3
    • 2
    • 1
    Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Rabbit Polyclonal antibody to UBE3A (ubiquitin protein ligase E3A)
    UBE3A antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human UBE3A. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product ube3a Primary Antibody
  • Application Notes
    ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.26 mg/mL
    Buffer
    1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    ube3a (Ubiquitin Protein Ligase E3A (ube3a))
    Alternative Name
    ubiquitin protein ligase E3A (ube3a Products)
    Background
    This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

    Cellular Localization: Nucleus
    Molecular Weight
    100 kDa
    Gene ID
    7337
    UniProt
    Q05086
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway
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