TGFBI antibody

Catalog No. ABIN2854853

Product Details anti-TGFBI Antibody

Target: TGFBI (Transforming Growth Factor, beta-Induced, 68kDa (TGFBI))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGFBI antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Chicken, Human

Characteristics: Rabbit polyclonal antibody to TGFBI (transforming growth factor, beta-induced, 68 kDa)
TGFBI antibody [C1C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human TGFBI. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HeLa

Validation: Orthogonal

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1XPBS ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

References for anti-TGFBI antibody (ABIN2854853)

Brzozowski, Bond, Jankowski, Goldie, Burchell, Naudin, Smith, Scarlett, Larsen, Dun, Skelding, Weidenhofer: "Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion." in: Scientific reports, Vol. 8, Issue 1, pp. 8822, (2019) (PubMed).

Target Details for TGFBI

Target: TGFBI (Transforming Growth Factor, beta-Induced, 68kDa (TGFBI))

Alternative Name: transforming growth factor beta induced (TGFBI Products)

Background: This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.

Cellular Localization: Secreted , extracellular space , extracellular matrix

Molecular Weight: 75 kDa

Gene ID: 7045

UniProt: Q15582