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POLG antibody (C-Term)

POLG Reactivity: Human WB, IHC (p), IF, ICC, IP Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2854742
  • Target See all POLG Antibodies
    POLG (Polymerase (DNA Directed), gamma (POLG))
    Binding Specificity
    • 15
    • 9
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 52
    • 27
    • 24
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 52
    • 2
    Rabbit
    Clonality
    • 51
    • 3
    Polyclonal
    Conjugate
    • 19
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This POLG antibody is un-conjugated
    Application
    • 37
    • 15
    • 13
    • 13
    • 10
    • 10
    • 7
    • 7
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunoprecipitation (IP)
    Cross-Reactivity
    Human, Rat
    Characteristics
    Rabbit Polyclonal antibody to DNA polymerase gamma (polymerase (DNA directed), gamma)
    DNA polymerase gamma antibody
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the C-terminus region of human DNA polymerase gamma. The exact sequence is proprietary.
    Isotype
    IgG
  • Application Notes
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: Rat testis , MCF-7 , MDA-MB-231

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.67 mg/mL
    Buffer
    1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    POLG (Polymerase (DNA Directed), gamma (POLG))
    Alternative Name
    DNA polymerase gamma (POLG Products)
    Synonyms
    POLG antibody, MDP1 antibody, MIRAS antibody, MTDPS4A antibody, MTDPS4B antibody, PEO antibody, POLG1 antibody, POLGA antibody, SANDO antibody, SCAE antibody, AA409516 antibody, PolgA antibody, polymerase (DNA) gamma, catalytic subunit L homeolog antibody, DNA polymerase gamma, catalytic subunit antibody, polymerase (DNA directed), gamma antibody, polg.L antibody, Polg antibody, POLG antibody, polg antibody
    Target Type
    Viral Protein
    Background
    Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.

    Cellular Localization: Mitochondrion
    Molecular Weight
    140 kDa
    Gene ID
    5428
    UniProt
    P54098
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