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ADRA2C antibody (C-Term)

ADRA2C Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2854717
  • Target See all ADRA2C Antibodies
    ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))
    Binding Specificity
    • 23
    • 23
    • 16
    • 10
    • 8
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 82
    • 47
    • 20
    • 7
    • 4
    • 4
    • 2
    • 1
    Human
    Host
    • 59
    • 26
    Rabbit
    Clonality
    • 59
    • 26
    Polyclonal
    Conjugate
    • 31
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ADRA2C antibody is un-conjugated
    Application
    • 55
    • 25
    • 20
    • 17
    • 15
    • 14
    • 13
    • 13
    • 11
    • 11
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Cross-Reactivity
    Human
    Characteristics
    Rabbit Polyclonal antibody to alpha 2c Adrenergic Receptor (adrenergic, alpha-2C-, receptor)
    alpha 2c Adrenergic Receptor antibody [C2C3], C-term
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human alpha 2c Adrenergic Receptor. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product ADRA2C Primary Antibody
  • Application Notes
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: HeLa

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.62 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    ADRA2C (Adrenergic, alpha-2C-, Receptor (ADRA2C))
    Alternative Name
    adrenoceptor alpha 2C (ADRA2C Products)
    Synonyms
    ADRA2L2 antibody, ADRA2RL2 antibody, ADRARL2 antibody, ALPHA2CAR antibody, Adra-2c antibody, [a]2C antibody, alpha2-C4 antibody, alpha2C antibody, zgc:194523 antibody, zgc:194541 antibody, adra2c antibody, ADRA2B antibody, ADRA2C antibody, adrenoceptor alpha 2C antibody, adrenergic receptor, alpha 2c antibody, ADRA2C antibody, Adra2c antibody, adra2c antibody
    Background
    Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.

    Cellular Localization: Cell membrane
    Molecular Weight
    50 kDa
    Gene ID
    152
    UniProt
    P18825
    Pathways
    EGFR Signaling Pathway, cAMP Metabolic Process
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