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HAAO antibody

HAAO Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2854465
  • Target See all HAAO Antibodies
    HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
    Reactivity
    • 20
    • 11
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 25
    • 1
    Rabbit
    Clonality
    • 25
    • 1
    Polyclonal
    Conjugate
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HAAO antibody is un-conjugated
    Application
    • 21
    • 13
    • 13
    • 10
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Rabbit Polyclonal antibody to HAAO (3-hydroxyanthranilate 3,4-dioxygenase)
    HAAO antibody [N1C3]
    Purification
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein encompassing a sequence within the center region of human HAAO. The exact sequence is proprietary.
    Isotype
    IgG
    Top Product
    Discover our top product HAAO Primary Antibody
  • Application Notes
    WB: 1:500-1:10000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
    Comment

    Positive Control: Mouse liver , HepG2

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal
    Preservative
    Thimerosal (Merthiolate)
    Precaution of Use
    This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
  • Target
    HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))
    Alternative Name
    3-hydroxyanthranilate 3,4-dioxygenase (HAAO Products)
    Background
    3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

    Cellular Localization: Cytoplasm
    Molecular Weight
    33 kDa
    Gene ID
    23498
    UniProt
    P46952
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