FMO1 antibody

Catalog No. ABIN2854460

Product Details anti-FMO1 Antibody

Target: FMO1 (Flavin Containing Monooxygenase 1 (FMO1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FMO1 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human

Characteristics: Rabbit polyclonal antibody to FMO1 (flavin containing monooxygenase 1)
FMO1 antibody [N1C2]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human FMO1. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: HepG2 , Raji

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for FMO1

Target: FMO1 (Flavin Containing Monooxygenase 1 (FMO1))

Alternative Name: flavin containing monooxygenase 1 (FMO1 Products)

Synonyms: RFMO1A antibody, flavin containing monooxygenase 1 antibody, FMO1 antibody, fmo1 antibody, Fmo1 antibody

Background: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.

Cellular Localization: Microsome membrane , Endoplasmic reticulum membrane

Molecular Weight: 60 kDa

Gene ID: 2326

UniProt: Q01740