CRYGC antibody

Catalog No. ABIN2854417

Product Details anti-CRYGC Antibody

Target: CRYGC (Crystallin, gamma C (CRYGC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRYGC antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Mouse

Characteristics: Rabbit polyclonal antibody to Gamma-crystallin C (crystallin, gamma C)
gamma C Crystallin antibody [N1C3]

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human gamma C Crystallin. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:20000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: A431 , mouse eye

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for CRYGC

Target: CRYGC (Crystallin, gamma C (CRYGC))

Alternative Name: crystallin gamma C (CRYGC Products)

Synonyms: Cryg antibody, Cryg3 antibody, Len antibody, CCL antibody, CRYG3 antibody, CTRCT2 antibody, Cryg-5 antibody, ccl antibody, cryg3 antibody, MGC84008 antibody, CRYGC antibody, crystallin, gamma C antibody, crystallin gamma C antibody, crystallin gamma C L homeolog antibody, gamma-crystallin C antibody, Crygc antibody, CRYGC antibody, crygc.L antibody, LOC100069179 antibody

Background: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.

Molecular Weight: 21 kDa

Gene ID: 1420

UniProt: P07315