NUP98 antibody

Catalog No. ABIN2854401

Product Details anti-NUP98 Antibody

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUP98 antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Monkey

Characteristics: Rabbit polyclonal antibody to NUP98 (nucleoporin 98 kDa)
NUP98 antibody [N1N2], N-term

Purification: Affinity purified by Protein A.

Immunogen: Recombinant protein encompassing a sequence within the center region of human NUP98. The exact sequence is proprietary.

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment:

Positive Control: cos 7

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.39 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 10 % Glycerol, 0.01 % Thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Target Details for NUP98

Target: NUP98 (Nucleoporin 98kDa (NUP98))

Alternative Name: nucleoporin 98 (NUP98 Products)

Synonyms: CG10198 antibody, CG10201 antibody, Dmel\\CG10198 antibody, Nup 96 antibody, Nup 98 antibody, Nup-98 antibody, Nup96 antibody, Nup98 antibody, Nup98-Nup96 antibody, Nup98/96 antibody, l(3)95BCd antibody, nup145 antibody, nup98-96 antibody, GB12688 antibody, NUP98 antibody, 4732457F17 antibody, AI849286 antibody, im:7151238 antibody, zgc:113968 antibody, zgc:63593 antibody, ADIR2 antibody, NUP196 antibody, NUP96 antibody, Nucleoporin 98-96kD antibody, nuclear pore complex protein Nup98-Nup96 antibody, nucleoporin 98 antibody, nucleoporin 98kDa antibody, nucleoporin 98 L homeolog antibody, Nup98-96 antibody, LOC408335 antibody, NUP98 antibody, LOC587580 antibody, Nup98 antibody, nup98 antibody, nup98.L antibody

Background: Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants, however, not all variants have been fully described.

Cellular Localization: Nucleus , nuclear pore complex , Nucleus membrane, Peripheral membrane protein, Nucleoplasmic side

Molecular Weight: 198 kDa

Gene ID: 4928

UniProt: P52948

Pathways: Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interactome