FOXP3 antibody (Biotin)
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- Target See all FOXP3 Antibodies
- FOXP3 (Forkhead Box P3 (FOXP3))
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Reactivity
- Mouse
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Host
- Rat
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Clonality
- Monoclonal
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Conjugate
- This FOXP3 antibody is conjugated to Biotin
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Application
- Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- This antibody reacts with mouse Foxp3.
- Purification
- Protein G agarose
- Clone
- MF-14
- Isotype
- IgG2b
- Top Product
- Discover our top product FOXP3 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.2 mg/mL
- Buffer
- PBS containing 1 % BSA and 0.09 % NaN3
- Storage
- 4 °C
- Storage Comment
- Store at 2-8 °C.
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- Target
- FOXP3 (Forkhead Box P3 (FOXP3))
- Alternative Name
- FOXP3 (FOXP3 Products)
- Synonyms
- foxp3 antibody, FOXP3 antibody, AIID antibody, DIETER antibody, IPEX antibody, PIDX antibody, XPID antibody, JM2 antibody, scurfin antibody, sf antibody, RGD1562112 antibody, forkhead box P3 antibody, forkhead box P3a antibody, forkhead box P3 L homeolog antibody, FOXP3 antibody, foxp3a antibody, foxp3 antibody, foxp3.L antibody, Foxp3 antibody
- Background
- Forkhead-winged helix P3 (Foxp3), also known as Scurfin or JM2, is a 50-55 kDa transcription factor, originally identified as the gene defective in Scurfy mice. Scurfy mice and humans with similar mutations spontaneously develop autoimmune diseases (IPEX). Resent reports revealed that Foxp3 is expressed in CD4 + CD25 + regulatory T cells (Treg cells), and ectopic expression of Foxp3 in CD4 + Foxp3 - T cells induced a Treg-like phenotype in these cells. Importantly, these reports indicate that Foxp3 is a specific marker for Treg cells. Taken together, Foxp3 is believed to be a crucial regulator of the development and function of Treg cells.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin
- Gene ID
- 20371
- NCBI Accession
- NP_001186276
- UniProt
- Q99JB6
- Pathways
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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