CD44 antibody (FITC)

Catalog No. ABIN2853597

Product Details anti-CD44 Antibody (FITC)

Target: CD44

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD44 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Specificity: This antibody reacts with CD44 antigen.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A agarose beads

Immunogen: MML-1 human leukemia cells

Clone: 15C6

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.05 mg/mL

Buffer: PBS, 0.09 % NaN3, 1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8 °C.

Target Details for CD44

Target: CD44

Alternative Name: CD44 (CD44 Products)

Synonyms: CDW44 antibody, CSPG8 antibody, ECMR-III antibody, HCELL antibody, HUTCH-I antibody, IN antibody, LHR antibody, MC56 antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody, Pgp1 antibody, AU023126 antibody, AW121933 antibody, AW146109 antibody, HERMES antibody, Ly-24 antibody, Pgp-1 antibody, CD44A antibody, METAA antibody, RHAMM antibody, XCD44 antibody, cd44 antibody, cdw44 antibody, cspg8 antibody, ecmr-iii antibody, hcell antibody, lhr antibody, mc56 antibody, mdu2 antibody, mdu3 antibody, mic4 antibody, mutch-i antibody, pgp1 antibody, CD44 molecule (Indian blood group) antibody, syndecan 4 antibody, CD44 antigen antibody, CD44 molecule (Indian blood group) S homeolog antibody, CD44 antibody, SDC4 antibody, Cd44 antibody, cd44.S antibody

Background: CD44, also known as H-CAM, Homing Cell Adhesion Molecule, and Pgp-1 is a highly glycosylated transmembrane protein expressed by lymphocytes, fibroblasts, smooth muscle cells, and epithelial cells. CD44 functions as lymphocyte adhesion molecule, acting as a matrix receptor that mediates cell adhesion to the extracellular matrix. CD44 is also involved in T-lymphocyte activation, lymphocyte homing, cell migration, and hematopoiesis. Expression of CD44 on the cell surface changes profoundly during tumor metastasis, and the transition from non-metastatic to metastatic tumor cell variants is associated with expression of CD44 variants (CD44v's), making CD44 a potential cancer marker. CD44 has a predicted molecular weight of 85-90 kDa, but glycosylation can increase the apparent MW to ~200 kDa.Synonyms: CDw44, ECMR-III, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, LHR, MDU2, MDU3, MIC4, PGP-1, Phagocytic glycoprotein 1

Gene ID: 960

NCBI Accession: NP_000601

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling