RUNX2 antibody (pSer465)

Catalog No. ABIN389942

Product Details anti-RUNX2 Antibody

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Binding Specificity: pSer465

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUNX2 antibody is un-conjugated

Application: Dot Blot (DB)

Specificity: This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S533 of human RUNX2.

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RUNX2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S465 of human RUNX2.

Clone: RB15321

Isotype: Ig Fraction

Application Details

Application Notes: DB = 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-RUNX2 antibody (ABIN389942)

Fu, Wang, Lu, Ma, Ke, Liu, Luo: "In vitro inhibitory effects of terpenoids from Chloranthus multistachys on epithelial-mesenchymal transition via down-regulation of Runx2 activation in human breast cancer." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 22, Issue 1, pp. 165-72, (2015) (PubMed).

Wang, Cai, Ma, Liu, Ke, Lu, Fu: "The natural compound codonolactone impairs tumor induced angiogenesis by downregulating BMP signaling in endothelial cells." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 22, Issue 11, pp. 1017-26, (2015) (PubMed).

Fu, Ke, Tan, Liu, Wang, Ma, Lu: "The natural compound codonolactone attenuates TGF-?1-mediated epithelial-to-mesenchymal transition and motility of breast cancer cells." in: Oncology reports, (2015) (PubMed).

Wang, Chen, Zou, Tu, Tan, Lu, Liu, Fu: "Codonolactone, a sesquiterpene lactone isolated from Chloranthus henryi Hemsl, inhibits breast cancer cell invasion, migration and metastasis by downregulating the transcriptional activity of Runx2." in: International journal of oncology, Vol. 45, Issue 5, pp. 1891-900, (2014) (PubMed).

Tsimbouri, Murawski, Hamilton, Herzyk, Oreffo, Gadegaard, Dalby: "A genomics approach in determining nanotopographical effects on MSC phenotype." in: Biomaterials, Vol. 34, Issue 9, pp. 2177-84, (2013) (PubMed).

Tsimbouri, McMurray, Burgess, Alakpa, Reynolds, Murawski, Kingham, Oreffo, Gadegaard, Dalby: "Using nanotopography and metabolomics to identify biochemical effectors of multipotency." in: ACS nano, Vol. 6, Issue 11, pp. 10239-49, (2012) (PubMed).

McNamara, Sjöström, Burgess, Kim, Liu, Gordonov, Moghe, Meek, Oreffo, Su, Dalby: "Skeletal stem cell physiology on functionally distinct titania nanotopographies." in: Biomaterials, Vol. 32, Issue 30, pp. 7403-10, (2011) (PubMed).

Tetsunaga, Nishida, Furumatsu, Naruse, Hirohata, Yoshida, Saito, Ozaki: "Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 19, Issue 2, pp. 222-32, (2011) (PubMed).

Target Details for RUNX2

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Alternative Name: RUNX2 (RUNX2 Products)

Background: Synonyms: Runt-related transcription factor 2, Core-binding factor subunit alpha-1, CBF-alpha-1, Acute myeloid leukemia 3 protein, Oncogene AML-3, Polyomavirus enhancer-binding protein 2 alpha A subunit, PEBP2-alpha A, PEA2-alpha A, SL3-3 enhancer factor 1 alpha A

Molecular Weight: 56648 DA

Gene ID: 860

UniProt: Q13950