Klotho antibody (C-Term)

Catalog No. ABIN389493

Product Details anti-Klotho Antibody

Target: Klotho (KL)

Binding Specificity: AA 986-1012, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Klotho antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Specificity: This Klotho antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 983~1012 amino acids from the C-terminal region of human Klotho.

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Klotho antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 986-1012 AA from the C-terminal region of human Klotho.

Clone: RB21226

Isotype: Ig Fraction

Application Details

Application Notes: WB = 1:1000, FACS = 1:10-50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-Klotho antibody (ABIN389493)

Cheng, Chen, Cheng: "Decrease of Klotho in the kidney of streptozotocin-induced diabetic rats." in: Journal of biomedicine & biotechnology, Vol. 2010, pp. 513853, (2010) (PubMed).

Target Details for Klotho

Target: Klotho (KL)

Alternative Name: Klotho (KL Products)

Synonyms: alpha-kl antibody, KL antibody, LOC100223456 antibody, klotho antibody, Klotho antibody, KL antibody, Kl antibody, kl antibody, LOC100533542 antibody

Background: Klotho is a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
Synonyms: Klotho, Klotho peptide, KL

Molecular Weight: 116181 DA

Gene ID: 9365

UniProt: Q9UEF7

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hormone Activity, Growth Factor Binding