TSC1 antibody (AbBy Fluor® 594)
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- Target See all TSC1 Antibodies
- TSC1 (Tuberous Sclerosis 1 (TSC1))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TSC1 antibody is conjugated to AbBy Fluor® 594
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Sheep
- Predicted Reactivity
- Human,Mouse,Rat,Dog,Cow,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Hamartin
- Isotype
- IgG
- Top Product
- Discover our top product TSC1 Primary Antibody
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- Application Notes
- IF(IHC-P) 1:50-200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- TSC1 (Tuberous Sclerosis 1 (TSC1))
- Alternative Name
- Hamartin/ TSC1 (TSC1 Products)
- Synonyms
- LAM antibody, TSC antibody, hamartin antibody, mKIAA0243 antibody, tsc1 antibody, wu:fc38b04 antibody, fa99f04 antibody, wu:fa99f04 antibody, zgc:63657 antibody, TSC complex subunit 1 antibody, tuberous sclerosis 1 antibody, TSC complex subunit 1b antibody, TSC complex subunit 1a antibody, TSC1 antibody, Tsc1 antibody, tsc1b antibody, tsc1 antibody, tsc1a antibody
- Background
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Synonyms: LAM, TSC1, Tuberous sclerosis 1 protein, TSC1_HUMAN.
Background: Hamartin, or TSC1, is a suspected tumor suppressor implicated in the disease tuberous sclerosis 1. It is a negative regulator of cell division controlling the transition from G0/G1 to S phase, and it seems to act through the phosphatidylinositol 3 kinase/Akt pathway. TSC1 interacts with tuberin m(TSC2), which is thought to be a GAP (GTPase Activating Protein) for the Rap1 and Rab5 small G Proteins. The Hamartin/Tuberin complex has been shown to inhibit mTor. Hamartin has also been shown to interact with ERM (Ezrin-Radixin-Moesin) proteins and with F-actin, suggesting a role for TSC proteins in modulation of cell adhesion and morphology.
- Gene ID
- 7248
- UniProt
- Q92574
- Pathways
- RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation
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