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EXOSC10 antibody (AA 41-140) (AbBy Fluor® 594)

EXOSC10 Reactivity: Human, Mouse WB, IF (cc), IF (p) Host: Rabbit Polyclonal AbBy Fluor® 594
Catalog No. ABIN2812977
  • Target See all EXOSC10 Antibodies
    EXOSC10 (Exosome Component 10 (EXOSC10))
    Binding Specificity
    • 14
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 41-140
    Reactivity
    • 34
    • 22
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 33
    • 2
    Rabbit
    Clonality
    • 33
    • 2
    Polyclonal
    Conjugate
    • 19
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EXOSC10 antibody is conjugated to AbBy Fluor® 594
    Application
    • 30
    • 12
    • 12
    • 11
    • 6
    • 6
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Human, Mouse
    Predicted Reactivity
    Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human EXOSC10/PMSCL2
    Isotype
    IgG
    Top Product
    Discover our top product EXOSC10 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    EXOSC10 (Exosome Component 10 (EXOSC10))
    Alternative Name
    EXOSC10/PMSCL2 (EXOSC10 Products)
    Synonyms
    Pmscl2 antibody, zgc:55695 antibody, pm-scl antibody, pm/scl-100 antibody, pmscl antibody, pmscl2 antibody, rrp6 antibody, rrp6p antibody, EXOSC10 antibody, 201.t00018 antibody, 21.m02990 antibody, DDBDRAFT_0203581 antibody, DDBDRAFT_0233752 antibody, DDB_0203581 antibody, DDB_0233752 antibody, PM-Scl antibody, PM/Scl-100 antibody, PMSCL antibody, PMSCL2 antibody, RRP6 antibody, Rrp6p antibody, p2 antibody, p3 antibody, p4 antibody, exosome component 10 antibody, 3'-5' exonuclease antibody, exosome component 10 L homeolog antibody, exosc10 antibody, EXOSC10 antibody, EHI_021400 antibody, BBOV_IV002650 antibody, CpipJ_CPIJ003896 antibody, CMU_031760 antibody, Tsp_05247 antibody, exosc10.L antibody, Exosc10 antibody
    Background

    Synonyms: Autoantigen PM/Scl 2, Exosc10, Exosome component 10, EXOSX_HUMAN, P100 polymyositis scleroderma overlap syndrome associated autoantigen, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen, p2, p3, p4, PM Scl, PM/Scl 100, PM/Scl-100, PMSCL, PMSCL2, Polymyositis/scleroderma autoantigen 100 kDa, Polymyositis/scleroderma autoantigen 2 100 kDa, Polymyositis/scleroderma autoantigen 2, RRP6, Rrp6p.

    Background: The exosome is a multi-subunit complex composed of several highly conserved proteins, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3? region. EXOSC10, also known as PMSCL, PMSCL2, p2, p3, p4, RRP6, Rrp6p, PM-Scl, or PM/Scl-100, is an 885 amino acid protein that contains one HRDC domain and one 3?-5? enonuclease domain. Localized to both the cytoplasm and the nucleus, EXOSC10 is part of the post-splicing exosome complex and is involved in mRNA surveillance, mRNA nuclear export and nonsense-mediated decay of mRNAs containing premature stop codons. against EXOSC10 have been found in patients with scleroderma and/or polymyositis (chronic diseases of the skin and muscle, respectively), suggesting that EXOSC10 may be involved in the pathogenesis of these diseases. Two isoforms of EXOSC10 exist due to alternative splicing events.

    Gene ID
    5394
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