PDE4DIP antibody (AbBy Fluor® 594)

Catalog No. ABIN2811765

Product Details anti-PDE4DIP Antibody (AbBy Fluor® 594)

Target: PDE4DIP (phosphodiesterase 4D Interacting Protein (PDE4DIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE4DIP antibody is conjugated to AbBy Fluor® 594

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CMYA2/PDE4DIP

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PDE4DIP

Target: PDE4DIP (phosphodiesterase 4D Interacting Protein (PDE4DIP))

Alternative Name: CMYA2 (PDE4DIP Products)

Background:

Synonyms: Cardiomyopathy associated protein 2, Cardiomyopathy-associated protein 2, CMYA2, MMGL, MYOME_HUMAN, Myomegalin, Pde4dip, Phosphodiesterase 4D interacting protein, Phosphodiesterase 4D-interacting protein.

Background: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes.Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events.

Gene ID: 9659

Pathways: SARS-CoV-2 Protein Interactome