AGAP2 antibody (AA 981-1080) (AbBy Fluor® 594)
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- Target See all AGAP2 Antibodies
- AGAP2 (ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2))
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Binding Specificity
- AA 981-1080
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This AGAP2 antibody is conjugated to AbBy Fluor® 594
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human
- Predicted Reactivity
- Mouse,Rat,Dog,Cow,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Centaurin gamma 1
- Isotype
- IgG
- Top Product
- Discover our top product AGAP2 Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- AGAP2 (ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2))
- Alternative Name
- Centaurin gamma 1 (AGAP2 Products)
- Synonyms
- zgc:153779 antibody, CENTG1 antibody, GGAP2 antibody, PIKE antibody, Centg1 antibody, mKIAA0167 antibody, Pike antibody, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 antibody, AGAP2 antibody, agap2 antibody, Agap2 antibody
- Background
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Synonyms: Centaurin gamma 1, ANK repeat and PH domain-containing protein 2, AGAP-2, Agap2, Agap2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2, AGAP2_HUMAN, ANK repeat and PH domains 2, Arf GAP with GTP binding protein like, Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2, Arf GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2, Arf-GAP with GTPase, Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2, centaurin gamma1, Centaurin-gamma-1, Centg1, cnt g1, Cnt-g1, Cnt2, GGAP2, GTP binding and GTPase activating protein 2, GTP-binding and GTPase activating protein 2, GTP-binding and GTPase-activating protein 2, Nuclear GTPase PIKE, Phosphatidylinositol-3-kinase enhancer, Phosphoinositide 3 kinase enhancer, PI3K ENHANCER, PIKE.
Background: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
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