DRAXIN antibody (AA 251-349) (AbBy Fluor® 594)
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- Target See all DRAXIN Antibodies
- DRAXIN (Dorsal Inhibitory Axon Guidance Protein (DRAXIN))
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Binding Specificity
- AA 251-349
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DRAXIN antibody is conjugated to AbBy Fluor® 594
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- Predicted Reactivity
- Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Chicken,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human C1orf187
- Isotype
- IgG
- Top Product
- Discover our top product DRAXIN Primary Antibody
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- Application Notes
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- DRAXIN (Dorsal Inhibitory Axon Guidance Protein (DRAXIN))
- Alternative Name
- C1orf187 (DRAXIN Products)
- Synonyms
- C1orf187 antibody, draxin antibody, AGPA3119 antibody, UNQ3119 antibody, neucrin antibody, 2610109H07Rik antibody, MGC113312 antibody, dorsal inhibitory axon guidance protein antibody, DRAXIN antibody, Draxin antibody, draxin antibody
- Background
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Synonyms: AGPA3119, C1orf187, Chromosome 1 open reading frame 187, Dorsal inhibitory axon guidance protein, Dorsal repulsive axon guidance protein, DRAXI_HUMAN, Draxin, FLJ34999, MGC117222, Neucrin, OTTHUMP00000002262, UNQ3119.
Background: C1orf187, also known as Draxin, Dorsal repulsive axon guidance protein and Neucrin, is a 349 amino acid secreted protein that is required of the development of the spinal cord and forebrain commissures. C1orf187 acts as a chemorepulsive guidance protein and directs commissural axons during development by repelling neurite outgrowth from the spinal cord. During development, C1orf187 modulates neural crest migration by reducing the polarization of these cells, leading to reduced velocity of migration and increased frequency of changing direction, leading to a net decrease in migrational distance. It acts as an antagonist of the Wnt signaling pathway by inhibiting the stabilization of cytosolic _-catenin via its interaction with LRP6. C1orf187 inhibits outgrowth from the olfactory bulb and likely contributes to the formation of the lateral olfactory tract.
- Gene ID
- 374946
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