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EYA1 antibody (AA 231-330)

EYA1 Reactivity: Human ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2808274
  • Target See all EYA1 Antibodies
    EYA1 (Eyes Absent Homolog 1 (EYA1))
    Binding Specificity
    • 15
    • 14
    • 10
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 231-330
    Reactivity
    • 34
    • 24
    • 8
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    Human
    Host
    • 44
    • 1
    • 1
    Rabbit
    Clonality
    • 46
    Polyclonal
    Conjugate
    • 18
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EYA1 antibody is un-conjugated
    Application
    • 27
    • 22
    • 12
    • 12
    • 4
    • 2
    • 2
    • 2
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
    Cross-Reactivity
    Human
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human EYA1
    Isotype
    IgG
    Top Product
    Discover our top product EYA1 Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    EYA1 (Eyes Absent Homolog 1 (EYA1))
    Alternative Name
    EYA1 (EYA1 Products)
    Synonyms
    EYA1 antibody, bop antibody, bor antibody, XEya1 antibody, wu:fc13c10 antibody, zgc:100770 antibody, BOP antibody, BOR antibody, BOS1 antibody, EYA transcriptional coactivator and phosphatase 1 antibody, EYA transcriptional coactivator and phosphatase 1 L homeolog antibody, EYA1 antibody, eya1 antibody, Eya1 antibody, eya1.L antibody
    Background

    Synonyms: BOP, BOR, BOS1, OFC1, Eyes absent homolog 1, EYA1

    Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development, in this it is functionally redundant with EYA2.

    Gene ID
    2138
    UniProt
    Q99502
    Pathways
    Sensory Perception of Sound, Positive Regulation of Response to DNA Damage Stimulus
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