ZNRF2 antibody (AbBy Fluor® 594)

Catalog No. ABIN2807712

Product Details anti-ZNRF2 Antibody (AbBy Fluor® 594)

Target: ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNRF2 antibody is conjugated to AbBy Fluor® 594

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZNRF2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ZNRF2

Target: ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))

Alternative Name: ZNRF2 (ZNRF2 Products)

Synonyms: RNF202 antibody, 1190002C14Rik antibody, AU044205 antibody, D6Ertd365e antibody, zgc:152865 antibody, znrf2 antibody, Znrf1 antibody, zgc:171663 antibody, zinc and ring finger 2 antibody, zinc and ring finger 2b antibody, zinc and ring finger 2a antibody, ZNRF2 antibody, Znrf2 antibody, znrf2b antibody, znrf2a antibody

Background:

Synonyms: E3 ubiquitin-protein ligase ZNRF2, Protein Ells2, RING finger protein 202, Zinc/RING finger protein 2, Znrf2, ZNRF2_HUMAN.

Background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.

Gene ID: 223082

Pathways: Synaptic Membrane