LRSAM1 antibody (AbBy Fluor® 594)
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- Target See all LRSAM1 Antibodies
- LRSAM1 (Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1))
- Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LRSAM1 antibody is conjugated to AbBy Fluor® 594
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human LRSAM1
- Isotype
- IgG
- Top Product
- Discover our top product LRSAM1 Primary Antibody
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- Application Notes
- IF(IHC-P) 1:50-200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Expiry Date
- 12 months
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- Target
- LRSAM1 (Leucine Rich Repeat and Sterile alpha Motif Containing 1 (LRSAM1))
- Alternative Name
- LRSAM1 (LRSAM1 Products)
- Synonyms
- CMT2P antibody, RIFLE antibody, TAL antibody, leucine rich repeat and sterile alpha motif containing 1 antibody, LRSAM1 antibody, Lrsam1 antibody
- Background
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Synonyms: E3 ubiquitin protein ligase LRSAM1, hTAL, Leucine rich repeat and sterile alpha mot containing protein 1, RLE, TAL, Tsg101 associated ligase, LRSM1_HUMAN.
Background: LRSAM1 is an E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivation of the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos. It selectively regulates cell adhesion molecules and plays a role in receptor endocytosis and viral budding. LRSAM1 contains a RING-type zinc finger, 5 leucine-rich repeats and 1 SAM (sterile alpha motif) domain. The coiled coil domains interact with the SB domain of TSG101. The PTAP motifs mediate the binding to UEV domains. There are 3 isoforms produced by alternative splicing.
- Gene ID
- 90678
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