TCEB1 antibody (N-Term)
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- Target See all TCEB1 Antibodies
- TCEB1 (Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C) (TCEB1))
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Binding Specificity
- N-Term
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Reactivity
- Human, Dog, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TCEB1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EHALTSGTIK AMLSGPGQFA ENETNEVNFR EIPSHVLSKV CMYFTYKVRY
- Cross-Reactivity
- Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus)
- Predicted Reactivity
- Dog: 100%, Human: 100%, Zebrafish: 100%
- Characteristics
- This is a rabbit polyclonal antibody against TCEB1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human TCEB1
- Top Product
- Discover our top product TCEB1 Primary Antibody
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- Application Notes
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WB Suggested Anti-TCEB1 Antibody Titration: 0.2-1 µg/mL
Positive Control: Raji cell lysate.
Optimal working dilutions should be determined experimentally by the investigator. - Comment
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Antigen size: 112 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- TCEB1 (Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C) (TCEB1))
- Alternative Name
- TCEB1 (TCEB1 Products)
- Synonyms
- 2610043E24Rik antibody, 2610301I15Rik antibody, AA407206 antibody, AI987979 antibody, AW049146 antibody, SIII antibody, eloC antibody, TCEB1 antibody, fb09f09 antibody, wu:fb09f09 antibody, zgc:111990 antibody, zgc:92635 antibody, elongin C antibody, elongin C L homeolog antibody, transcription elongation factor B (SIII), polypeptide 1b antibody, Eloc antibody, eloc.L antibody, ELOC antibody, tceb1b antibody
- Background
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TCEB1 is known as protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Western blots using two different antibodies (P100962-T200 and P100963_P050 / P100963_P100) against two unique regions of this protein target confirm the same apparent molecular weight in our tests.
Alias Symbols: SIII, eloC
Protein Interaction Partner: UBC, TCEB2, FUS, vif, METTL21C, SOCS4, CUL5, PRAME, POP1, MDM2, VHL, ASB18, ASB12, ASB14, ASB15, ASB9, ASB8, ASB7, ASB5, ASB10, ASB16, ASB13, ASB1, ASB3, APEX1, CUL2, Zswim8, ASB2, CPTP, CBX5, MRAS, JTB, RCAN2, SOCS1, CUL3, WNT7B, NEDD8, HIF1A, EFNB3, CYP
Protein Size: 112 - Molecular Weight
- 12 kDa
- Gene ID
- 6921
- NCBI Accession
- NM_005648, NP_005639
- UniProt
- Q15369
- Pathways
- SARS-CoV-2 Protein Interactome
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