GTF2H2 antibody (C-Term)
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- Target See all GTF2H2 Antibodies
- GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Horse, Zebrafish (Danio rerio), Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GTF2H2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- CELPVECKIC GLTLVSAPHL ARSYHHLFPL DAFQEIPLEE YNGERFCYGC
- Cross-Reactivity
- Cow (Bovine), Dog (Canine), Chicken, Human, Mouse (Murine), Rat (Rattus)
- Predicted Reactivity
- Dog: 92%, Horse: 92%, Human: 100%, Mouse: 85%, Zebrafish: 85%
- Characteristics
- This is a rabbit polyclonal antibody against GTF2H2. It was validated on Western Blot.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human GTF2H2
- Top Product
- Discover our top product GTF2H2 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 395 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- GTF2H2 (General Transcription Factor IIH, Polypeptide 2, 44kDa (GTF2H2))
- Alternative Name
- GTF2H2 / BTF2P44 (GTF2H2 Products)
- Synonyms
- 44kDa antibody, BTF2 p44 antibody, BTF2-p44 antibody, Btf2p44 antibody, p44 antibody, BTF2 antibody, BTF2P44 antibody, T-BTF2P44 antibody, TFIIH antibody, general transcription factor II H, polypeptide 2 antibody, general transcription factor IIH subunit 2 antibody, general transcription factor IIH, polypeptide 2, 44kDa antibody, Gtf2h2 antibody, GTF2H2 antibody
- Background
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GTF2 is encoded by a gene that is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs, however, no sequence data is currently available for the centromeric copy of the gene.
Alias Symbols: p44, BTF2, TFIIH, BTF2P44, T-BTF2P44
Protein Interaction Partner: UBC, CDK7, GTF2H5, GTF2H1, SRA1, GTF2H4, GTF2H3, UBD, COPS2, ERCC3, ERCC8, ERCC2, AR, MNAT1, CCNH,
Protein Size: 395 - Molecular Weight
- 44 kDa
- Gene ID
- 2966
- NCBI Accession
- NM_001515, NP_001506
- UniProt
- Q13888
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
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