EGR2 antibody (C-Term)

Catalog No. ABIN2792631

Product Details anti-EGR2 Antibody

Target: EGR2 (Early Growth Response 2 (EGR2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Horse, Pig, Cow, Dog, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EGR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: PFACDYCGRK FARSDERKRH TKIHLRQKER KSSAPSASVP APSTASCSGG

Cross-Reactivity: Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)

Predicted Reactivity: Cow: 100%, Dog: 92%, Horse: 85%, Human: 100%, Mouse: 100%, Pig: 92%, Rabbit: 92%, Rat: 92%

Characteristics: This is a rabbit polyclonal antibody against EGR2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human EGR2

Application Details

Application Notes: WB Suggested Anti-EGR2 Antibody Titration: 0.2-1 µg/mL
ELISA Titer: 1:312500
Positive Control: Human Lung.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 476 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-EGR2 antibody (ABIN2792631)

Damm, Mylonas, Cosson, Yoshida, Della Valle, Mouly, Diop, Scourzic, Shiraishi, Chiba, Tanaka, Miyano, Kikushige, Davi, Lambert, Gautheret, Merle-Béral, Sutton, Dessen, Solary, Akashi, Vainchenker et al.: "Acquired initiating mutations in early hematopoietic cells of CLL patients. ..." in: Cancer discovery, Vol. 4, Issue 9, pp. 1088-101, (2014) (PubMed).

Lagrange, Martin, Droin, Aucagne, Paggetti, Largeot, Itzykson, Solary, Delva, Bastie: "A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages." in: Biochimica et biophysica acta, Vol. 1833, Issue 8, pp. 1936-46, (2013) (PubMed).

Latasa, Ituero, Moran-Gonzalez, Aranda, Cosgaya: "Retinoic acid regulates myelin formation in the peripheral nervous system." in: Glia, Vol. 58, Issue 12, pp. 1451-64, (2010) (PubMed).

Target Details for EGR2

Target: EGR2 (Early Growth Response 2 (EGR2))

Alternative Name: EGR2 (EGR2 Products)

Synonyms: AT591 antibody, CMT1D antibody, CMT4E antibody, KROX20 antibody, Egr-2 antibody, Krox-20 antibody, Krox20 antibody, NGF1-B antibody, Zfp-25 antibody, Zfp-6 antibody, KRX-20 antibody, cb427 antibody, egr2 antibody, id:ibd5073 antibody, krox20 antibody, krx20 antibody, wu:fb71h10 antibody, zgc:92210 antibody, frb35 antibody, early growth response 2 antibody, early growth response 2b antibody, early growth response 2a antibody, EGR2 antibody, Egr2 antibody, egr2b antibody, egr2a antibody

Background: The early growth response protein 2 (EGR2) is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1.The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CMT1D, CMT4E, DKFZp686J1957, FLJ14547, KROX20, AT591
Protein Interaction Partner: RPL7L1, HN1L, RIMKLB, RBM15B, NDUFS2, BPGM, SRA1, DTX1, WWP2, UBC, UBE2I, NAB2, SOX8, MED31, SOX10, HCFC1, ACP5, NFATC1, FASLG,
Protein Size: 476

Molecular Weight: 50 kDa

Gene ID: 1959

NCBI Accession: NM_000399, NP_000390

UniProt: P11161