PAX2A antibody (Middle Region)

Catalog No. ABIN2792620

Product Details anti-PAX2A Antibody

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Zebrafish (Danio rerio), Cow, Dog, Rabbit, Sheep, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAX2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: VSSASNDPVG SYSINGILGI PRSNGEKRKR DEDVSEGSVP NGDSQSGVDS

Cross-Reactivity: Chicken, Human, Mouse (Murine), Rat (Rattus)

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 92%, Sheep: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against PAX2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PAX2

Application Details

Application Notes: WB Suggested Anti-PAX2 Antibody Titration: 1.0 µg/mL
ELISA Titer: 1:312500
Positive Control: Human Liver.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 417 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PAX2A

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Alternative Name: PAX2 (PAX2A Products)

Synonyms: PAPRS antibody, Opdc antibody, Pax-2 antibody, Pax-2a antibody, XPax-2 antibody, XPax2 antibody, pax-2 antibody, pax2 antibody, xPax-2a antibody, PAXZF-B antibody, cb378 antibody, noi antibody, pax-b antibody, pax2.1 antibody, pax2a1 antibody, pax[zf-b] antibody, paxb antibody, pax2.2 antibody, paired box 2 antibody, paired box 2 L homeolog antibody, paired box 2a antibody, paired box 2b antibody, PAX2 antibody, Pax2 antibody, pax2.L antibody, pax2a antibody, pax2b antibody

Background: PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia.
Protein Interaction Partner: BBS7, BBS4, BBS2, BBS1, RB1, BRCA1, SFRP2, PAXIP1, WT1, MAPK8IP1, MAPK8, ID2,
Protein Size: 417

Molecular Weight: 45 kDa

Gene ID: 5076

NCBI Accession: NM_003988, NP_003979

UniProt: Q02962

Pathways: Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation