TCF4 antibody (N-Term)

Catalog No. ABIN311751

Product Details anti-TCF4 Antibody

Target: TCF4 (Transcription Factor 4 (TCF4))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Rat, Horse, Guinea Pig, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCF4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DGTPYDHMTS RDLGSHDNLS PPFVNSRIQS KTERGSYSSY GRESNLQGCH

Cross-Reactivity: Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)

Predicted Reactivity: Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against TCF4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TCF4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 667 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TCF4

Target: TCF4 (Transcription Factor 4 (TCF4))

Alternative Name: TCF4 (TCF4 Products)

Background: TCF4 encodes transcription factor 4, a basic helix-turn-helix transcription factor. The protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. TCF4 is expressed predominantly in pre-B-cells, although it is found in other tissues as well.TCF4 encodes transcription factor 4, a basic helix-turn-helix transcription factor. The protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. TCF4 is expressed predominantly in pre-B-cells, although it is found in other tissues as well. TCF4 is known to produce multiple transcripts, however as the complete structure is only known for the transcript that encodes the b isoform, that is the variant presented here.
Alias Symbols: E2-2, ITF2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, PTHS, ITF-2, SEF-2, TCF-4, bHLHb19
Protein Interaction Partner: GOLGA8F, REXO1L6P, FAM74A4, GOLGA8EP, C9orf171, RAB41, SEC14L4, NEK8, ZDHHC24, MSRB3, FERD3L, PPP1R18, NUDT10, PATE1, TMEM213, KLC3, ZNF417, NEU4, NR2C2AP, POLR1A, SZT2, EPB41L3, MAPKBP1, SLC4A1AP, FRS3, NEK6, GLRX3, MAD2L2, BCAS2, TSSC4, CHAF1A, POLR1C,
Protein Size: 667

Molecular Weight: 71 kDa

Gene ID: 6925

NCBI Accession: NM_003199, NP_003190

UniProt: P15884

Pathways: WNT Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus