MYBL2 antibody (N-Term)

Catalog No. ABIN2792568

Product Details anti-MYBL2 Antibody

Target: MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2))

Binding Specificity: N-Term

Reactivity: Human, Rat, Dog, Cow, Horse, Guinea Pig, Rabbit, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYBL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: RCEDLDELHY QDTDSDVPEQ RDSKCKVKWT HEEDEQLRAL VRQFGQQDWK

Cross-Reactivity: Cow (Bovine), Dog (Canine), Chicken, Human, Rat (Rattus)

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Rabbit: 92%, Rat: 78%, Zebrafish: 83%

Characteristics: This is a rabbit polyclonal antibody against MYBL2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MYBL2

Application Details

Application Notes: WB Suggested Anti-MYBL2 Antibody Titration: 0.2-1 µg/mL
Positive Control: HepG2 cell lysate.
Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 700 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-MYBL2 antibody (ABIN2792568)

Tashiro, Sumi, Uozumi, Shimizu, Nakamura: "B-Myb-dependent regulation of c-Myc expression by cytosolic phospholipase A2." in: The Journal of biological chemistry, Vol. 279, Issue 17, pp. 17715-22, (2004) (PubMed).

Target Details for MYBL2

Target: MYBL2 (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 (MYBL2))

Alternative Name: MYBL2 (MYBL2 Products)

Synonyms: MYBL2 antibody, bmyb antibody, b-myb antibody, B-Myb antibody, Bmyb antibody, B-MYB antibody, BMYB antibody, myb1 antibody, MYB proto-oncogene like 2 antibody, v-myb avian myeloblastosis viral oncogene homolog-like 2b antibody, myeloblastosis oncogene-like 2 antibody, MYB proto-oncogene like 2 S homeolog antibody, MYBL2 antibody, mybl2 antibody, mybl2b antibody, Mybl2 antibody, mybl2.S antibody

Background: Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.
Alias Symbols: BMYB, B-MYB
Protein Interaction Partner: CCNA1, CDK2, CCNE1, LIN54, SPTBN1, SPTA1, FLNA, CLTC, CLTA, LIN9, UBE2D4, CXCR4, LIN52, LIN37, RBL1, RBBP4, SUMO2, MAP1LC3B, MAPK6, NLK, HIPK2, CREBBP, ZBTB9, TRIM15, LZTR1, CDK9, ZNF622, UBB, TTF2, EP300, SND1, SKP2, MYBL2, NCOR1, NCOR2, PARP1, CCND1, CC
Protein Size: 700

Molecular Weight: 79 kDa

Gene ID: 4605

NCBI Accession: NM_002466, NP_002457

UniProt: P10244

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases, Chromatin Binding