RAB8A antibody (Middle Region)

Catalog No. ABIN2792290

Product Details anti-RAB8A Antibody

Target: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Dog, Cow, Pig, Sheep, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB8A antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GIKFMETSAK ANINVENAFF TLARDIKAKM DKKLEGNSPQ GSNQGVKITP

Predicted Reactivity: Cow: 100%, Dog: 100%, Human: 100%, Mouse: 85%, Pig: 100%, Rat: 85%, Sheep: 100%, Zebrafish: 85%

Characteristics: This is a rabbit polyclonal antibody against RAB8A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RAB8A

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 207 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RAB8A

Target: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Alternative Name: RAB8A (RAB8A Products)

Synonyms: rab8A antibody, DDBDRAFT_0206521 antibody, DDBDRAFT_0214885 antibody, DDB_0206521 antibody, DDB_0214885 antibody, HSH2D antibody, mel antibody, rab8 antibody, c-mel antibody, MEL antibody, RAB8 antibody, zgc:162699 antibody, AA409338 antibody, Mel antibody, Rab8 antibody, rab8A protein antibody, Rab GTPase antibody, RAB8A, member RAS oncogene family antibody, RAB8A, member RAS oncogene family S homeolog antibody, rab8A antibody, RAB8A antibody, rab8a antibody, rab8a.S antibody, Rab8a antibody

Background: RAB8A is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable.The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97 % , 96 %, and 51 % similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: MEL, RAB8
Protein Interaction Partner: TFRC, SYTL4, SYTL1, TBC1D17, STAU1, UBC, MDM2, RPA3, RPA2, RPA1, STK4, OPTN, Myo5b, MYO5C, EHD3, EHD1, UBL4A, RAB1B, RAB31, COX5A, RAB11B, RAB7A, SCP2, RRBP1, NDUFA7, IDH3G, SNCA, ELAVL1, Rab8a, RPH3A, RAB3IP, RIMS2, RPH3AL, RABIF, MAP4K2, PDE6D, GDI2, OC
Protein Size: 207

Molecular Weight: 24 kDa

Gene ID: 4218

NCBI Accession: NM_005370, NP_005361

UniProt: P61006

Pathways: M Phase, Regulation of long-term Neuronal Synaptic Plasticity, SARS-CoV-2 Protein Interactome