RGS10 antibody (Middle Region)

Catalog No. ABIN2792213

Product Details anti-RGS10 Antibody

Target: RGS10 (Regulator of G-Protein Signaling 10 (RGS10))

Binding Specificity: Middle Region

Reactivity: Human, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS10 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Sequence: DQIFNLMKYD SYSRFLKSDL FLKHKRTEEE EEDLPDAQTA AKRASRIYNT

Predicted Reactivity: Cow: 81%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Rabbit: 90%, Rat: 90%

Characteristics: This is a rabbit polyclonal antibody against RGS10. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RGS10

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 181 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for RGS10

Target: RGS10 (Regulator of G-Protein Signaling 10 (RGS10))

Alternative Name: RGS10 (RGS10 Products)

Synonyms: MGC82511 antibody, RGS10 antibody, 2310010N19Rik antibody, regulator of G-protein signaling 10 antibody, regulator of G-protein signaling 10 L homeolog antibody, regulator of G protein signaling 10 antibody, regulator of G-protein signalling 10 antibody, RGS10 antibody, rgs10.L antibody, rgs10 antibody, Rgs10 antibody

Background: RGS10 inhibits signal transduction by increasing the GTPASE activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. It associates specifically with the activated forms of the G protein subunits G(I)-ALPHA and G(Z)- alpha but fails to interact with the structurally and functionally distinct G(S)-alpha subunit. Activity on G(Z)-alpha is inhibited by palmitoylation of the G-protein.
Protein Interaction Partner: UBC, ADRB2, APP, PRKACA, GNAI3, GNAO1, GNAI1, GNAZ, GNRHR, CALM1, ACP6, SAP18, EIF6,
Protein Size: 181

Molecular Weight: 21 kDa

Gene ID: 6001

NCBI Accession: NM_001005339, NP_001005339

UniProt: Q96GN0

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling