CDKN1B antibody (C-Term)
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- Target See all CDKN1B Antibodies
- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CDKN1B antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- EQCAGIRKRP ATDDSSTQNK RANRTEENVS DGSPNAGSVE QTPKKPGLRR
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against CDKN1B. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human CDKN1B
- Top Product
- Discover our top product CDKN1B Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 198 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort." in: Breast cancer research : BCR, Vol. 10, Issue 3, pp. R47, (2008) (PubMed).
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Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort." in: Breast cancer research : BCR, Vol. 10, Issue 3, pp. R47, (2008) (PubMed).
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- Target
- CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
- Alternative Name
- CDKN1B (CDKN1B Products)
- Synonyms
- CDKN4 antibody, KIP1 antibody, MEN1B antibody, MEN4 antibody, P27KIP1 antibody, cdkn1b antibody, sb:cb611 antibody, wu:fb63g10 antibody, wu:fb64g10 antibody, wu:fe18e03 antibody, CDKN1B antibody, Kip1 antibody, p27 antibody, FAM14D antibody, ISG12 antibody, ISG12A antibody, P27 antibody, Cdki1b antibody, AA408329 antibody, AI843786 antibody, p27Kip1 antibody, cdkn1bl antibody, cyclin dependent kinase inhibitor 1B antibody, cyclin-dependent kinase inhibitor 1Bb antibody, interferon alpha inducible protein 27 antibody, cyclin-dependent kinase inhibitor 1B antibody, cyclin-dependent kinase inhibitor 1Ba antibody, CDKN1B antibody, cdkn1bb antibody, IFI27 antibody, Cdkn1b antibody, cdkn1ba antibody
- Background
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CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: CDKN4, KIP1, MEN1B, MEN4, P27KIP1
Protein Interaction Partner: CCND1, UBC, SGK1, PSMB1, CDK4, SKP2, CDK5, CDK3, CDK2, CDK1, SKP1, CKS1B, CCNE1, CCND3, CAMK1, YWHAQ, CCNA2, ABL1, TSC2, LYN, STMN1, RHOA, RPS6KA1, IRF1, KPNA6, CCNE2, CCNA1, VCP, SRC, MAPK10, MAPK8, CDC34, CDK6, RCHY1, COPS5, CUL1, HIST1H1A, CUL4A, JAK2,
Protein Size: 198 - Molecular Weight
- 22 kDa
- Gene ID
- 1027
- NCBI Accession
- NM_004064, NP_004055
- UniProt
- P46527
- Pathways
- Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy
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