Osteoprotegerin antibody (N-Term)
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- Target See all Osteoprotegerin (TNFRSF11B) Antibodies
- Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
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Binding Specificity
- N-Term
- Reactivity
- Human, Mouse, Rat, Rabbit, Dog, Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Osteoprotegerin antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- LDISIKWTTQ ETFPPKYLHY DEETSHQLLC DKCPPGTYLK QHCTAKWKTV
- Predicted Reactivity
- Dog: 78%, Horse: 78%, Human: 100%, Mouse: 85%, Pig: 78%, Rabbit: 78%, Rat: 78%
- Characteristics
- This is a rabbit polyclonal antibody against TNFRSF11B. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human TNFRSF11B
- Top Product
- Discover our top product TNFRSF11B Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 401 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- Osteoprotegerin (TNFRSF11B) (Tumor Necrosis Factor Receptor Superfamily, Member 11b (TNFRSF11B))
- Alternative Name
- TNFRSF11B (TNFRSF11B Products)
- Synonyms
- CD254 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, RANKL antibody, TRANCE antibody, hRANKL2 antibody, sOdf antibody, OCIF antibody, OPG antibody, TR1 antibody, Opg antibody, ocif antibody, opg antibody, tr1 antibody, TNF superfamily member 11 antibody, TNF receptor superfamily member 11b antibody, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) antibody, TNF receptor superfamily member 11B antibody, tumor necrosis factor receptor superfamily member 11b S homeolog antibody, tumor necrosis factor receptor superfamily, member 11b antibody, TNFSF11 antibody, TNFRSF11B antibody, Tnfrsf11b antibody, tnfrsf11b.S antibody
- Target Type
- Chemical
- Background
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TNFRSF11B is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Alias Symbols: OPG, TR1, OCIF
Protein Interaction Partner: TNFSF13, TNFSF10, TNFSF11, VWF, VTN, THBS1, FN1,
Protein Size: 401 - Molecular Weight
- 46 kDa
- Gene ID
- 4982
- NCBI Accession
- NM_002546, NP_002537
- UniProt
- O00300
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