TXN antibody (C-Term)

Catalog No. ABIN2792061

Product Details anti-TXN Antibody

Target: TXN (Thioredoxin (TXN))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Cow, Pig, Rabbit, Dog, Guinea Pig, Horse, Sheep

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%

Characteristics: This is a rabbit polyclonal antibody against TXN. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human TXN

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TXN

Target: TXN (Thioredoxin (TXN))

Alternative Name: TXN (TXN Products)

Background: TXN participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. It plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. It nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. It induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55)
Alias Symbols: TRDX, TRX, TRX1
Protein Interaction Partner: NR3C1, GPX1, APEX1, SRP9, PARK2, TXNIP, UBD, Melk, NPM1, PAN2, UBL4A, UBC, DYNLT1, SIAH1, NFE2, MYD88, MYC, MLH1, IFIT3, CDKN1A, ACTN4, GPRASP2, HCVgp1, PRDX1, MAP3K5, SFXN1, UBL5, UBQLN4, TAX1BP3, AHCYL1, SSSCA1, SYNCRIP, WDR1, ATP6V1F, UBE2V1, UBE2D2, S
Protein Size: 105

Molecular Weight: 11 kDa

Gene ID: 7295

NCBI Accession: NM_003329, NP_003320

UniProt: P10599

Pathways: Carbohydrate Homeostasis, Cell RedoxHomeostasis