SLX1A/GIYD2 antibody (N-Term)

Catalog No. ABIN2791914

Product Details anti-SLX1A/GIYD2 Antibody

Target: SLX1A/GIYD2 (SLX1B) (SLX1 Structure-Specific Endonuclease Subunit Homolog B (SLX1B))

Binding Specificity: N-Term

Reactivity: Human, Mouse, Horse, Guinea Pig, Rabbit, Rat, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLX1A/GIYD2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: FFGVYLLYCL NPRYRGRVYV GFTVNTARRV QQHNGGRKKG GAWRTSGRGP

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against SLX1B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SLX1B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for SLX1A/GIYD2

Target: SLX1A/GIYD2 (SLX1B) (SLX1 Structure-Specific Endonuclease Subunit Homolog B (SLX1B))

Alternative Name: SLX1B (SLX1B Products)

Synonyms: 1110030E23Rik antibody, 2410170E21Rik antibody, 4833422P03Rik antibody, AI853643 antibody, Giyd1 antibody, Giyd2 antibody, LRRGT00058 antibody, RGD1311568 antibody, GIYD2 antibody, SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) antibody, SLX1 homolog B, structure-specific endonuclease subunit antibody, Slx1b antibody, SLX1B antibody

Background: This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication, this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene.
Protein Interaction Partner: SLX4, THAP11, DUSP10, TUBA1B, LOC344382, EME1, SLX4IP, SLIRP, MUS81, GEMIN6, PAGR1, FKBP10, GEMIN4, DDX20, TIMM17B, PSME3, SLC25A13, HUWE1, PSMD6, CUL1, UQCRC2, SMN1, S100A8, RAN, PSMD11, PSMB5, PSMB3, PSMB2, PSMB1, PSMA7, PSMA6, PSMA5, PSMA4, PSMA3, PSMA
Protein Size: 275

Molecular Weight: 30 kDa

Gene ID: 79008

UniProt: Q9BQ83

Pathways: DNA Damage Repair