Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis. Protein Interaction Partner: UBC, NPM1, MRPL41, DDX28, TSR1, MRPL39, MRPL51, MRPL13, ERLEC1, MRPL3, CUL7, RPS18, MRPL12, MRPL23, ICT1, HNRNPU, MRPL49, APP, MRPL55, TMEM177, MRPL32, MRPL38, MRPL40, Protein Size: 64