MVB12B antibody (C-Term)

Catalog No. ABIN2791520

Product Details anti-MVB12B Antibody

Target: MVB12B (Multivesicular Body Subunit 12B (MVB12B))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MVB12B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: HISLTLPATF RGRNSTRTDY EYQHSNLYAI SAMDGVPFMI SEKFSCVPES

Predicted Reactivity: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 85%, Rabbit: 93%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against MVB12B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MVB12B

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for MVB12B

Target: MVB12B (Multivesicular Body Subunit 12B (MVB12B))

Alternative Name: MVB12B (MVB12B Products)

Synonyms: C9orf28 antibody, FAM125B antibody, 2610200O14Rik antibody, 2610528K11Rik antibody, AI414895 antibody, Fam125b antibody, RGD1309709 antibody, fam125b antibody, mvb12b antibody, fam125ba antibody, zgc:152929 antibody, multivesicular body subunit 12B antibody, multivesicular body subunit 12B S homeolog antibody, multivesicular body subunit 12Ba antibody, MVB12B antibody, Mvb12b antibody, mvb12b.S antibody, mvb12ba antibody

Background: The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: C9orf28, MVB12B
Protein Interaction Partner: LNX1, gag, UBC, VPS37A, MVB12A, TSG101,
Protein Size: 319

Molecular Weight: 35 kDa

Gene ID: 89853

NCBI Accession: NM_033446, NP_258257

UniProt: Q9H7P6