MVB12B antibody (C-Term)
MVB12B
Reactivity: Human, Mouse, Rat, Guinea Pig, Rabbit, Cow, Dog, Horse
WB
Host: Rabbit
Polyclonal
unconjugated
1 image
-
- Target See all MVB12B Antibodies
- MVB12B (Multivesicular Body Subunit 12B (MVB12B))
- Binding Specificity
- C-Term
- Reactivity
- Human, Mouse, Rat, Guinea Pig, Rabbit, Cow, Dog, Horse
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This MVB12B antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Sequence
- HISLTLPATF RGRNSTRTDY EYQHSNLYAI SAMDGVPFMI SEKFSCVPES
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 85%, Rabbit: 93%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against MVB12B. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human MVB12B
- Top Product
- Discover our top product MVB12B Primary Antibody
-
-
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Target
- MVB12B (Multivesicular Body Subunit 12B (MVB12B))
- Alternative Name
- MVB12B (MVB12B Products)
- Background
-
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: C9orf28, MVB12B
Protein Interaction Partner: LNX1, gag, UBC, VPS37A, MVB12A, TSG101,
Protein Size: 319 - Molecular Weight
- 35 kDa
- Gene ID
- 89853
- NCBI Accession
- NM_033446, NP_258257
- UniProt
- Q9H7P6
-
You are here:
