PLD6 antibody (C-Term)

Catalog No. ABIN2791346

Product Details anti-PLD6 Antibody

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLD6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ITEDDEYVRL FLEEFERIWE QFNPTKYTFF PPKKSHGSCA PPVSRAGGRL

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against PLD6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human PLD6

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 252 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for PLD6

Target: PLD6 (Phospholipase D Family, Member 6 (PLD6))

Alternative Name: PLD6 (PLD6 Products)

Synonyms: ZUC antibody, 4933433K01Rik antibody, Gm10 antibody, Zuc antibody, mZuc antibody, mitoPLD antibody, pld6 antibody, fc55d08 antibody, wu:fc55d08 antibody, phospholipase D family member 6 antibody, phospholipase D family, member 6 antibody, phospholipase D family member 6 S homeolog antibody, PLD6 antibody, Pld6 antibody, pld6.S antibody, pld6 antibody

Background: PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
Alias Symbols: -
Protein Interaction Partner: ELAVL1, UBC,
Protein Size: 252

Molecular Weight: 28 kDa

Gene ID: 201164

NCBI Accession: NM_178836, NP_849158

UniProt: Q8N2A8

Pathways: Ribonucleoprotein Complex Subunit Organization