C1orf86 antibody (C-Term)
C1ORF86
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
1 image
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- Target See all C1orf86 (C1ORF86) products
- C1orf86 (C1ORF86) (Chromosome 1 Open Reading Frame 86 (C1ORF86))
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Binding Specificity
- C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This C1orf86 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- ARSLPQRPAP DPCRAPRVEQ QPSVEGAAAL RSCPMCQKEF APRLTQLDVD
- Predicted Reactivity
- Human: 100%
- Characteristics
- This is a rabbit polyclonal antibody against C1orf86. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human C1orf86
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 180 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- C1orf86 (C1ORF86) (Chromosome 1 Open Reading Frame 86 (C1ORF86))
- Alternative Name
- C1orf86 (C1ORF86 Products)
- Synonyms
- FAAP20 antibody, FP7162 antibody, Fanconi anemia core complex associated protein 20 antibody, FAAP20 antibody
- Background
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C1orf86 is a component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. It promotes translesion synthesis via interaction with REV1.
Alias Symbols: FP7162
Protein Interaction Partner: FANCL, FANCA, UBC, FANCC, APITD1, C19orf40, C17orf70, FANCM, REV1, FANCG, FANCF, FANCB, FANCE, ELAVL1,
Protein Size: 180 - Molecular Weight
- 19 kDa
- Gene ID
- 199990
- NCBI Accession
- NM_182533, NP_872339
- UniProt
- Q6NZ36
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