KNSTRN antibody (Middle Region)

Catalog No. ABIN2791244

Product Details anti-KNSTRN Antibody

Target: KNSTRN (Kinetochore-Localized Astrin/SPAG5 Binding Protein (KNSTRN))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Rabbit, Saccharomyces cerevisiae, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNSTRN antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TDTATRRNVR KGYKPLSKQK SEEELKDKNQ LLEAVNKQLH QKLTETQGEL

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 85%, Rabbit: 100%, Rat: 79%, Yeast: 82%

Characteristics: This is a rabbit polyclonal antibody against C15orf23. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human C15orf23

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 316 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KNSTRN

Target: KNSTRN (Kinetochore-Localized Astrin/SPAG5 Binding Protein (KNSTRN))

Alternative Name: C15orf23 (KNSTRN Products)

Synonyms: 1700025D04Rik antibody, C15orf23 antibody, D2Ertd750e antibody, SKAP antibody, Traf4af1 antibody, TRAF4AF1 antibody, kinetochore-localized astrin/SPAG5 binding antibody, kinetochore localized astrin/SPAG5 binding protein antibody, kinetochore-localized astrin/SPAG5 binding protein antibody, Knstrn antibody, KNSTRN antibody

Background: C15orf23 is an essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. It promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.
Alias Symbols: SKAP, TRAF4AF1, C15orf23
Protein Interaction Partner: UBC, CLU, CHMP1B, MAPK6, Cep152, Cep55, Dynll1, Mad2l1, Spag5, Knstrn, Plk1, MPHOSPH6, MPP6,
Protein Size: 316

Molecular Weight: 35 kDa

Gene ID: 90417

NCBI Accession: NM_033286, NP_150628

UniProt: Q9Y448

Pathways: M Phase