TTI2 antibody (N-Term)

Catalog No. ABIN2790934

Product Details anti-TTI2 Antibody

Target: TTI2 (TELO2 Interacting Protein 2 (TTI2))

Binding Specificity: N-Term

Reactivity: Human, Pig, Rabbit, Cow, Dog, Guinea Pig, Horse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTI2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: THSLEQPWTT PRSREVAREV LTSLLQVTEC GSVAGFLHGE NEDEKGRLSV

Predicted Reactivity: Cow: 100%, Dog: 92%, Guinea Pig: 75%, Horse: 100%, Human: 100%, Pig: 92%, Rabbit: 75%

Characteristics: This is a rabbit polyclonal antibody against TTI2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human TTI2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 508 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for TTI2

Target: TTI2 (TELO2 Interacting Protein 2 (TTI2))

Alternative Name: TTI2 (TTI2 Products)

Synonyms: C8orf41 antibody, TELO2 interacting protein 2 antibody, TTI2 antibody, Tti2 antibody

Background: TTI2 is a regulator of the DNA damage response (DDR). 'TTI2 is part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). 'TTI2, together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.
Alias Symbols: C8orf41
Protein Interaction Partner: FUS, UBC, SUMO1, NEDD8, EGFR, ELAVL1, RPAP3, PIH1D1, RUVBL2, TELO2, TTI1, RUVBL1, PRKDC, HSP90AA1, HSPA4,
Protein Size: 508

Molecular Weight: 56 kDa

Gene ID: 80185

NCBI Accession: NM_025115, NP_079391

UniProt: Q6NXR4