ATF7IP2 antibody (N-Term)

Catalog No. ABIN2790606

Product Details anti-ATF7IP2 Antibody

Target: ATF7IP2 (Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATF7IP2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EEIVHSETKL EQVVCSYQKP SRTTESPSRV FTEEAKDSLN TSENDSEHQT

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against ATF7IP2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ATF7IP2

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 543 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ATF7IP2

Target: ATF7IP2 (Activating Transcription Factor 7 Interacting Protein 2 (ATF7IP2))

Alternative Name: ATF7IP2 (ATF7IP2 Products)

Synonyms: MCAF2 antibody, 4930558K11Rik antibody, BC018510 antibody, Get-1 antibody, PSM2 antibody, activating transcription factor 7 interacting protein 2 antibody, ATF7IP2 antibody, Atf7ip2 antibody

Background: ATF7IP2 is a recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. It can both act as an activator or a repressor depending on the context. ATF7IP2 mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity.
Alias Symbols: FLJ12668, MCAF2
Protein Interaction Partner: SETDB1, SP1, MBD1,
Protein Size: 543

Molecular Weight: 59 kDa

Gene ID: 80063

NCBI Accession: NM_001256160, NP_001243089

UniProt: Q5U623